"Helpless to one's destiny" can be a direct translation of "身不由己的命运" in English. For a poetic expression that captures the essence of being at the mercy of fate, you might consider the following line:

"Life's capricious hand, a fate we cannot shun."
This line attempts to convey the feeling of being subjected to the whims of an unpredictable destiny, much like how a poem might encapsulate the essence of a situation.
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